Even with assisted reproductive technology, their chances of fathering a child appear to drop once they reach the age of 50, according to new research.
Even within Vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), the chances of attaining a live birth decreased considerably once a man reached the age of 50, according to research conducted among potential fathers both over and under the age of 50. However, paternal age did not appear to be a factor in the likelihood of miscarriage following assisted reproductive technology.
A Man’s Opportunities Of Becoming A Father Are Reduced As He Gets Older
However, the results of the experiments vary from case to case the experts have observed that at a certain age the male fertility faces a big challenge which leads to the trouble to be a father.
Though there are cases where men have become fathers even after 50 of his age, the probability for the same in certain cases is much reduced. The survey was conducted on several samples across the nation with their medical conditions, history, and fertility effects due to the weather conditions and area.
Dr. Bobby Najari, head of the Male Infertility Program at NYU Langone Health in New York City, said the study “wasn’t too shocking in that it revealed that older men have lower assisted reproductive technology outcomes, but it’s still a growing field of research.” “I believe it makes a substantial contribution to our understanding of this area of reproductive health.”
Dr. Guy Morris of the Centre for Reproductive and Genetic Health in London, one of the study’s authors, highlighted that delayed parenthood is growing increasingly frequent for both men and women throughout the world. In England and Wales, for example, 15% of infants born in 2016 had a father who was over 40.
According to the study, the father’s age may have an influence on the child’s health, citing a study from the United States that revealed that when a father’s age was over 45, it raised the chances of gestational diabetes in the mother, preterm delivery, and newborn convulsions.
Another study revealed a link between increasing paternal age and a variety of neuropsychiatric illnesses and other negative health outcomes in children.
The new research was carried out at the London-based Centre for Reproductive and Genetic Health. All of the couples were experiencing primary or secondary infertility and were undergoing IVF or ICSI utilizing a male partner’s sperm sample.
There were 4,271 males and 4,833 cycles in the research. A live birth occurred in about 41% of the cycles. Men over 50 had a 33 percent reduced chance of having a live birth.
According to existing data, older men had greater rates of DNA fragmentation, which is a measure of how effectively DNA is packed inside sperm, stated Najari. Other research has shown that larger levels of DNA fragmentation are linked to poor IVF results, such as early miscarriage or poor fertilization, he added.
According to Najari, this is one reason why older men may have worse IVF results. Another interesting result is that elderly males appear to have lower sperm mobility and sperm count.
“If you look at the American Urological Association recommendations, the definition of advanced paternal age would imply that you advise couples when the male is above the age of 40 about these possible poor health consequences in kids,” Najari said. “However, different research employs various definitions.
For example, this one uses 50 as the criterion of older age, which I believe is because there is no age where there is a very significant danger above this age and no risk below this age.”