Scientists at Massachusetts General Hospital (MGH) have discovered that the new hormone irisin has the capacity to drive the cognitive advantages of exercise, and hence offers tremendous promise for treating cognitive loss in Alzheimer’s disease.
This can be a groundbreaking discovery and the same Irisin released by muscles during exercise might be an effective treatment for Alzheimer’s disease, according to research published in Nature Metabolism.
Hormone Irisin And How It Can Help Treat Alzheimer’s
According to senior author Christiane Wrann, DVM, Ph.D., leader of the Program in Neuroprotection, “Preserving cognitive function is a serious problem in an expanding older population identifying important mediators of these neuroprotective advantages, such as irisin, have become a significant focus of study because fitness is known to have favorable impacts on brain health.
The role of Irisin is a prime one as far as the health and wellbeing of neurons are concerned. Though many more elements play a role at this juncture, the presence of this hormone may support the brain to counter this disease and have better control.
The flow of this hormone needs to be improved if one wants to control this medical condition and in such case, exercise can be the best and most effective option for an individual if he can go for it.
Their research yielded some promising results. Through research, they found that genetic deletion of irisin affects cognitive performance in exercise, aging, and Alzheimer’s disease.
The hippocampus is the first region of the brain to exhibit symptoms of Alzheimer’s disease because it retains memories. MGH also showed that increasing irisin levels in the circulation enhanced cognitive performance and neuroinflammation in Alzheimer’s disease-modeling mice.
The study also discovered that irisin protects against neuroinflammation by acting directly on glia cells in the brain. “It’s difficult to imagine anything better for brain health than daily exercise,” says co-author Rudy Tanzi, co-director of the McCance Center for Brain Health at MGH.
“Our findings shed new light on the mechanism involved: protecting against neuroinflammation, perhaps the biggest killer of brain neurons as we age.” “Because irisin does not particularly target amyloid plaques, on the other hand, it affects neuroinflammation directly.
Scientists who are doing research on the same are very much confident it might have positive impacts on neurodegenerative disorders other than Alzheimer’s.”
According to co-author Bruce Spiegelman of Dana-Farber Cancer Institute and Harvard Medical School, “what makes this study so significant, is that we establish irisin’s influence on cognitive performance in not one, but four separate mice models.” Spiegelman discovered irisin in 2012 and is a co-author.
Even after Alzheimer’s disease mice models developed considerable pathology, irisin therapy proved successful, giving researchers further hope. According to Wrann, “this might have ramifications for intervention in people with Alzheimer’s disease since therapy generally begins after patients become symptomatic.”
The researchers used mice to study the effects of irisin on the brain. Mice’s synapses and memory are protected by irisin in these studies. Because of this, connections and memory were affected when the mouse’s hippocampal cortex was deficient in the Increased amounts of irisin in the brain had a similar effect, improving both measures of brain health.
The information available to us is still expected to be just the tip of the iceberg and further research in this area is expected to bring out other unknown facts as well.
Unlike olden times we have advanced in all medical fields and now we have advance technology available to us which is helping to understand the complexities of the human brain. This research can help us understand Alzheimer’s in a much better way and we can come up with better treatments for the same.