In the journal The Lancet Microbe, scientists at Florida Atlantic University’s Schmidt College of Medicine and associates wrote a comment regarding genetic monitoring to prevent COVID 19.
For further than a decade, epidemiologic monitoring of infectious illnesses, or keeping an eye on the dispersion and patterns in occurrence by regular information collecting, aggregation, and distribution, has been the benchmark for illness management.
Genomic Surveillance To Prevent And Control COVID
Though its discovery and rising accessibility of efficient and affordable vaccinations offer the best hope for potential recovery from the more deadly COVID 19 epidemic, genetic monitoring is quickly becoming a critical requirement for efficient reduction and control.
The U.S leads the globe in COVID 19 instances recorded, yet it ranked 43rd in viral variation monitoring and genome analysis.
“Genomic surveillance leverages applications of next-generation sequencing and phylogenetic methods to facilitate greater early anticipation as well as initiation of effective strategies to mitigate and contain outbreaks of SARS-CoV-2 variants and other novel viruses,” said Janet D. Robishaw, Ph.D., first author, senior associate dean for research and chair of the Department of Biomedical Science in the Schmidt College of Medicine.
“Genomic sequencing has been useful in identifying mutations, including mutations that are associated with reduced vaccine efficacy or increased virus transmissibility.
Additional variants that have shared mutations are probably similar regarding their response to treatment, and further demonstrate the need for genomic surveillance.”
The experts have observed that during different phases of infection that are known as waves those who have suffered more are people with different genomes that lead to poor medical conditions after infection.
Those who have suffered much are with different genomes and hence experts have found it difficult for them to have a quick or even better recovery after infection.
The survey has checked a vast number of samples during different waves and checked their samples with genomes which have revealed such surprising facts. Those who are with a different sequence are saved at the very first level only.
The scientists add in the editorial that, like other RNA infections such as influenza, SARS-genome CoV-2 acquires polymorphisms over time.
Scientists may integrate revolutionary genomic analyses with more classic epidemiology approaches to provide a rapid phenotypic and immunologic characterization of novel variations of significance when the genetic code accumulates these nucleotides alterations.
In the case of the COVID 19, the scientists suggest that genome surveillance is critical for detecting phenotypic traits or immunologically distinct variations as they propagate across the United States and the remainder of the globe.
“In addition to leveraging these changes to identify different lineages of virus that might be spreading in a population, the availability of sequence information allows researchers to identify variants that might alter the detection, infectivity, or severity of the disease,” said Robishaw. “Particular interest has been focused on changes in the spike protein responsible for host cell binding and entry that could result in false negatives in existing diagnostic tests.
In addition, such variation could affect transmission rates, health outcomes, therapeutic responses, and vaccine effectiveness.”
They claim that enhancing worldwide monitoring and gene editing ability will help them respond more effectively to the existing disease outbreak by seizing untraceable novel variations not just in the sudden increase region, which affects viral entrance, but also in other parts of the bacterial chromosome that impact cell growth, fact-checking, and translation.
“Increased international collaborative efforts in epidemiology and genomics in high-income countries offer promise as well for low-income countries where mitigation and containment efforts can be deployed,” said Scott M. Alter, M.D., M.B.A., corresponding author and an associate professor of emergency medicine in the Schmidt College of Medicine.