What if the time of day you get your COVID-19 immunization has an effect on how many antibodies you produce? Research suggests that it is conceivable. It was hypothesized that their body’s internal clock might impact health care workers’ immune responses after researchers found higher antibody levels in those who had their vaccinations in the afternoon.

COVID Dose Timing May Affect Your Immune Response

SARS-CoV-2 immunization may be more effective if the vaccine is administered at the right time of day, according to researchers who conducted an observational study.

COVID Dose Timing May Affect Your Immune Response

A co-author of the paper, Dr. Elizabeth Klerman, offered her comments. She is a research investigator at Massachusetts General Hospital’s Sleep Disorders Unit. A vaccination against COVID-19, regardless of the time of day or night, is the most critical step in preventing infection, according to Klerman.

More than 2,800 healthcare workers who had been vaccinated in the UK were studied by her team, which evaluated their antibody levels. Samples of blood were taken during immunization. Antibody levels may be influenced by vaccination timing, kind of vaccine (Pfizer or AstraZeneca), age, gender, and the number of days following vaccination.

Antibody responses were found to be greater in those who received the immunization later in the day on average. People who received the Pfizer vaccine were not the only ones with more excellent antibody responses. But this research is contrary to prior studies in senior males who had higher anti-influenza titers after having flu shots in the morning, even though symptoms and treatment effectiveness may fluctuate depending on the time of day.

SARS-CoV-2 and influenza vaccines both have different methods of action, and antibody responses may change depending on whether the immune system recognizes the pathogen from past infections, such as influenza, or whether it is challenged with a new virus. Such as the SARS strain.”

Klerman was quoted in a hospital news release as saying. Weaknesses included a lack of information on the participants’ medical and pharmacological histories and their sleep and shift-work routines.

Klerman recommends that elderly adults and those with weak immune systems schedule their vaccines during the afternoon to get the most benefit from the vaccination. He said that more profound knowledge of the SARS-CoV-2 virus and the body’s reaction to immunization is needed before they can propose that people have their vaccine in the afternoon. For the first time, research has shown that SARS-CoV-2 vaccination responses are affected by the time of day.

Meanwhile, Klerman and her colleagues analyzed data on vaccine side effects collected from patients who had vaccines at Mass General and Brigham hospitals. To find out whether the time of day during which participants received the SARS-CoV-2 vaccine impacted its efficacy, she hopes to be given the opportunity to review data from randomized, controlled trials. It is probable that if the antibody levels are more significant in the afternoon, the detrimental consequences might be more severe. Klerman thought about this.